On native hardware, no. Through emulation (using a ROM) and applying a 60 FPS cheat/mod, yes, but it requires a very powerful PC.
据早期测试，用户需要在 PC 上准备好 Yuzu 模拟器本体、对应版本的 Nintendo Switch prod.keys 密钥文件，以及《索尼克：未知边境》的 （游戏卡带格式）或 NSP （数字版格式）文件。 sonic frontiers switch rom work
This is where the Switch ROM shines. The game is highly scalable on emulators if you have the PC hardware to back it up. On native hardware, no
A ROM file (typically in or .NSP format) is a digital dump of a Nintendo Switch game cartridge or digital download. XCI Files: Full dumps of physical cartridges. On native hardware