These unofficial "FIFA 16" ISO files are essentially heavily modded versions of a previous FIFA game. They are not a port of the actual FIFA 16 game you would play on a PS4.
: Open PCSX2, navigate to CDVD > ISO Selector > Browse , and choose your downloaded FIFA 16 file. Click System > Boot ISO (Fast) to launch the match. Tips for Optimizing Your Gameplay Performance
If you prefer playing on an actual CRT television or original hardware, your PS2 console must be modified.