Just like the first film, the plot is driven by an amnesiac scavenger hunt to find a missing wedding party member.

Central to the mystery is the return of the flamboyant, drug-dealing, and borderline psychotic Mr. Chow (Ken Jeong). Presumed dead after a staged shooting, Chow emerges as the only one who can possibly lead the Wolfpack to Teddy, leading to a series of explosive confrontations that up the ante far beyond anything seen in the first film.

The movie picks up where the first film left off. Phil Wenneck (Bradley Cooper), Stu Price (Ed Helms), Alan Garner (Zach Galifianakis), and Doug Billings (Justin Bartha) are still reeling from the events of the first film. The gang is invited to Thailand for Stu's wedding, and they decide to travel together, hoping to have a fun and relaxing time.