Modern emulation (specifically PCSX2) has made this process nearly seamless.
Many popular Steam and GOG versions of classic games rely on these community-made fixes to be playable on modern rigs: Prince of Persia Series Sands of Time ps2wide
The patches hosted on PS2Wide typically involve replacing or adding a few critical files to a game’s root directory: DLL Wrappers : Files like Modern emulation (specifically PCSX2) has made this process