Nintendo encrypted 3DS game cartridges and digital downloads to prevent piracy. When you insert a cartridge into a 3DS, the console's hardware uses internal keys to decrypt the game data on the fly, allowing it to be played.
The absolute best way to experience the game modernly is , available on Nintendo Switch, PlayStation 4, Xbox One, and PC (via Steam). rune factory 4 decrypted 3ds undub rom reg link
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The undub version is approximately 1.36 GiB and is typically provided as a .cia file. How to Use with Citra (Decryption) This public link is valid for 7 days