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When evaluating the "link" between a patient’s sleep profile and their ideal medication, clinical trials demonstrate clear advantages for the DORA class: Traditional GABA Agonists (Z-Drugs) Dual Orexin Receptor Antagonists (DORAs) Enhances broad inhibitory sedation. Selectively blocks wakefulness signals. Next-Day Grogginess High risk of morning "hangover" effect. Minimal, especially with short half-life variants. Cognitive Impairment Risks of anterograde amnesia and confusion. Preserves normal sleep architecture (REM/NREM). Dependency Risk High potential for tolerance and physical dependence. Significantly lower risk of abuse or rebound insomnia. 4. Safety Profiles and Patient Considerations