If your school allows Google Drive or Dropbox, you can technically install the game to a USB stick (a portable install) and run the .exe from the drive. This works 60% of the time, every time—provided the school’s IT doesn’t block external app execution.
Edmund McMillen and Nicalis actively protect their IP. Major unblocked repositories have been DMCA’d for hosting even the original Flash Isaac. The "Full Game" is a premium product, and the developers are rightfully defensive about it. The Binding Of Isaac Rebirth Full Game Unblocked
The local network filter cannot read your destination or traffic type, allowing you to bypass regional web blocks seamlessly. Note: Ensure you use a reputable, paid VPN service to maintain fast connection speeds and avoid data logging. Security Risks of "Free Unblocked" Websites If your school allows Google Drive or Dropbox,